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IlaSingh @ path.utah.edu
| Description | : | Inaccessible.
Our studies with XMRV consist of elucidating the role of this newly discovered virus in human prostate cancer. XMRV is the first gammaretrovirus known to infect humans. While gammaretroviruses have well-characterized oncogenic effects in animals, they have not been shown to cause human cancers... We found the virus in 27% of prostate cancers. XMRV proteins are expressed primarily in malignant epithelial cells, suggesting that retroviral infection may be directly linked to tumorigenesis. We have shown that XMRV-infection is associated with prostate cancer, especially higher-grade cancers... Transport into the nucleus needs to occur for the viral DNA to integrate into the host chromosome. Yet, we understand very little about how it occurs. HIV DNA can enter the nucleus of non-dividing cells, and these cells can serve as a reservoir for virus that remains inaccessible to anti-viral drugs" (www.path.utah.edu, 25.09.09) GOTO Complex GOTO NotKnown GOTO NewlyDiscovered GOTO InnovatorsNewRole GOTO HiddenChampionReservoir GOTO YetLiitleUnderstood GOTO WellUnderstood GOTO OurRightToChoose |
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